Depression is a psychological disorder characterized by obvious depressive emotions in clinical practice，accompanied by a decrease in interest or pleasure.Depression can seriously threaten the physical and mental health of patients and is the main cause of disability and global disease burden.In recent years，the number of patients with depression increased，but the treatment of depression is relatively limited.Currently，medication is the main treatment for depression in clinical practice，but there are also certain side effects.This study searched databases such as Pubmed，CNKI，CSPD，and CCD to review the literature on Tuina therapy for depression from October 2022.Clinical studies on Tuina alone and Tuina combined with other therapies for depression and subclinical depression were screened and reviewed.Tuina，as an environmentally friendly traditional Chinese medicine therapy，is based on meridians and acupoints.It regulates the patient's nervous and secretory systems through nerve reflexes and meridian systems，balancing their functions and achieving the effect of relaxing the brain，psychology，and muscles，thereby relieving depression and improving quality of life.It is worth promoting.This study aims to guide the clinical diagnosis and treatment of depression with tuina therapy，analyze its advantages and disadvantages，and provide suggestions for future research directions in tuina therapy for depression.