世界中医药
文章摘要
引用本文:徐健钦1,罗文舒2,杨卓欣2,何丽云3,海英4,张辉5,张春敏6,何列涛7,周鹏8,于海波2,王超3,刘佳3,黄杏贤2,蒋娇娜2,周玉梅2,曹雪梅2,马晓明2,闫兵2,杨福霞2,丘江宁2,王莉1,袁金筠1,朱燕娴1,徐玉芹1,刘凡2.基于真实世界观察针灸治疗轻中度产后抑郁障碍疗效的影响因素[J].世界中医药,2024,(07):.  
基于真实世界观察针灸治疗轻中度产后抑郁障碍疗效的影响因素
Factors Influencing the Effect of Acupuncture Treatment of Mild-to-moderate Postpartum Depression Based on Real-world Study
投稿时间:2023-11-28  
DOI:10.3969/j.issn.1673-7202.2024.07.004
中文关键词:  产后抑郁障碍  针刺疗法  真实世界研究  疗效影响因素  汉密尔顿抑郁量表  Cox回归  多中心
English Keywords:Postpartum depression  Acupuncture therapy  Real-world study  Factors influencing efficacy  Hamilton Depression Scale  Cox regression  Multicenter
基金项目:国家重点研发计划项目(2017YFC1703604);广东省中医药局科研项目(20231283);广东省医学科研基金项目(A2022116)
作者单位
徐健钦1,罗文舒2,杨卓欣2,何丽云3,海英4,张辉5,张春敏6,何列涛7,周鹏8,于海波2,王超3,刘佳3,黄杏贤2,蒋娇娜2,周玉梅2,曹雪梅2,马晓明2,闫兵2,杨福霞2,丘江宁2,王莉1,袁金筠1,朱燕娴1,徐玉芹1,刘凡2 1 广州中医药大学第四临床医学院深圳518033 2 深圳市中医院针灸科深圳518033 3 中国中医科学院临床基础医学研究所北京100700 4 辽宁中医药大学附属医院沈阳110033 5 中国医科大学附属盛京医院沈阳110136 6 河北省中医院石家庄050013 7 广西中医药大学第一附属医院南宁530022 8 深圳市宝安区中医院深圳518133 
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中文摘要:
      目的:基于真实世界观察针刺治疗轻中度产后抑郁障碍(PPD)疗效的影响因素。方法:前瞻性队列研究设计,通过国际针灸注册登记平台,收集真实世界中针灸治疗轻中度产后抑郁障碍的临床诊疗数据,共收集到来自6家医院的355例研究对象。将其以是否有效作为因变量,对年龄、病程、家人协助情况、孕期抑郁障碍史、抑郁程度、怀孕次数、流产情况、抑郁家族史、学历、针刺频次等变量进行单因素分析,筛选出与患者疗效相关的因素,再将其放入Cox回归模型进行多因素分析,探索影响针刺疗效的相关因素。结果:共纳入轻中度产后抑郁障碍受试者355例,其中329例评定为有效,有效率为92.7%。将经单因素分析后有统计学意义的因素纳入Cox回归模型中进行多因素分析,结果提示孕期抑郁障碍史、家人协助情况、针刺频次与针刺疗效具有相关性(均P<0.05)。结论:针刺治疗轻中度产后抑郁障碍有效,且针刺疗效与针刺频次、受试者家庭支持情况、孕期抑郁障碍病史相关(均P<0.05),孕期无抑郁障碍史、家人协助情况良好、针刺频次较高者针刺疗效更佳,且起效时间更短。
English Summary:
      Abstract〓Objective:To observe the influencing factors of acupuncture treatment effectiveness for mild-to-moderate postpartum depression(PPD) based on real-world data.Methods:A prospective cohort study design was employed.Clinical diagnosis and treatment data of acupuncture therapy for mild-to-moderate PPD in the real world were collected through the International Acupuncture Registration Platform.A total of 355 cases from six hospitals were included in the study.The effectiveness of acupuncture treatment was used as the dependent variable.Single-factor analysis was conducted on variables including age,duration of illness,family assistance status,history of antenatal depression,severity of depression,number of pregnancies,history of miscarriage,family history of depression,education level,and frequency of acupuncture sessions to identify factors related to patient efficacy.Subsequently,factors with statistical significance from the single-factor analysis were included in the Cox regression model for multifactor analysis to explore the relevant factors affecting acupuncture efficacy.Results:A total of 355 cases with mild-to-moderate PPD were included,among which 329 cases were assessed as effective,with an effectiveness rate of 92.7%.Factors with statistical significance from the single-factor analysis were included in the Cox regression model for multifactor analysis,indicating that a history of antenatal depression,family assistance status,and frequency of acupuncture sessions were correlated with acupuncture efficacy(all P<0.05).Conclusion:Acupuncture treatment is effective for mild-to-moderate PPD,and acupuncture efficacy is correlated with the frequency of acupuncture sessions,family support for the cases,and history of antenatal depression(all P<0.05).Cases without a history of antenatal depression,with good family support,and a higher frequency of acupuncture sessions showed better acupuncture efficacy and shorter onset time.
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