世界中医药
文章摘要
引用本文:潘欣渝,高云逸,方泽阳,魏军平.基于“玄府-络脉”新视角阐析糖尿病认知功能障碍[J].世界中医药,2024,(07):.  
基于“玄府-络脉”新视角阐析糖尿病认知功能障碍
Diabetic Cognitive Impairment Based on the New Perspective of “Sweat Pore-collateral Vessels”
投稿时间:2022-11-10  
DOI:10.3969/j.issn.1673-7202.2024.07.014
中文关键词:  玄府  络脉  糖尿病  认知功能障碍  风药  虫类药  中药  理论
English Keywords:Sweat pore  Collateral vessels  Diabetes  Cognitive impairment  Wind-related drugs  Insect drugs  Chinese medicine  Theory
基金项目:北京市自然基金项目(7202172)——从PERK-ATF4-CHOP信号通路探讨补肾活血方及其有效成分治疗DKD的机制;中医药循证能力建设项目(60104)——中医药防治2型糖尿病循证能力建设项目;中国中医科学院科技创新工程重大攻关项目(C12021A01617)——玉女煎治疗2型糖尿病热盛阴虚证的临床疗效评价及作用机制研究;中国中医科学院中医药“一带一路”国际合作专项课题(GH201907)——2型糖尿病轻度认知障碍中医虚实证候miRNA-LncRNA表达谱研究
作者单位
潘欣渝,高云逸,方泽阳,魏军平 中国中医科学院广安门医院北京100053 
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中文摘要:
      糖尿病认知功能障碍属于“消渴呆病”范畴,其病机本虚标实,以脏腑亏虚为本,痰瘀糖毒阻络为标。玄府、络脉是人体普遍存在的一种微观结构,具有维系周身气血津液运行的功能,玄府闭塞、络脉阻滞是多种疾病发生的病理基础。基于“玄府-络脉”的新视角,分析其与糖尿病认知功能障碍发病的关联性。玄府闭塞,脑络不通,神机失用是糖尿病认知功能障碍的病机,治宜以通为用,临证组方借虫类风药开玄通络,共增药效,为糖尿病认知功能障碍的临床治疗提供思路。
English Summary:
      Diabetic cognitive impairment belongs to the category of “mental deterioration due to consumptive thirst” in traditional Chinese medicine(TCM).Its pathogenesis is deficiency in root causes and excess in manifestations,with organ deficiency as the root and phlegm,stasis,and sugar toxin obstructing collaterals as the manifestation.Sweat pore and collateral vessels are microstructures universally present in the human body,with the function of maintaining the circulation of qi,blood,and body fluids throughout the body.Occlusion of sweat pore and blockage of collateral vessels serve as the pathological basis for the occurrence of various diseases.From the new perspective of “sweat pore-collateral vessels”,this study analyzed its correlation with the onset of diabetic cognitive impairment.The vital activity dysfunction resulting from occlusion of sweat pore and the blockage of collateral vessels in the brain is the pathogenesis of diabetic cognitive impairment.Treatment should focus on dredging.Clinically,formulas based on wind-related drugs derived from insects are adopted to open sweat pore and dredge collaterals,which can enhance the efficacy of treatment,providing insights into the clinical treatment of diabetic cognitive impairment.
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