世界中医药

目的：基于数据挖掘技术，探究叶桂治疗肿胀的用药配伍规律。方法：收集和整理《临证指南医案》肿胀篇医案及方药，用office 2010建立数据库，进行频数分析，应用IBM SPSS Modeler 18.0的Apriori算法进行关联规则分析，采用SPSS Statistics 26.0进行因子分析。结果：共纳入83例处方，涉及药物117味，用药频数共计527次，高频药（频次≧10次）共15味，其中最高频单味药为茯苓、厚朴、生白术，对药以桂枝-甘草的使用频次最高，药物类别以化痰药、温里药、利水渗湿药为主；药性以温性为主，寒热并调；药味以辛、苦为主；归经以归脾、胃、肺经者最多；聚类分析中将15味高频中药聚为7类时效果最佳；关联规则分析出2组最常用药对；因子分析共提取出6个公因子。结论：叶桂治疗肿胀以通阳利水为要法，善用茯桂剂以奏温中通阳，化气利水之功，重脾肺、倡温补、善通利，务在宣肺、健脾、温肾，扶阳助气，上下并调，使阳气通达全身，通条水利，恢复人体气、血、津、液的正常功能，以达营卫调和、肿胀自除之效。

English Summary:

Explore the medication combination patterns of Yegui in the treatment of swelling disease using data mining.Methods:Medical cases and prescriptions for swelling from the “Guide to Clinical Practice with Medical Records” were collected and organized.A database was established using office 2010，and frequency analysis was conducted.The Apriori algorithm in IBM SPSS Modeler 18.0 was used for association rule analysis，and factor analysis was performed using SPSS Statistics 26.0.Results:A total of 83 prescriptions were included，involving 117 drugs，with a total of 527 times of medication frequency.There were 15 high-frequency drugs(frequency≥10 times).Among them，the most high-frequency single drugs were Poria cocos，Magnolia officinalis，and Atractylodes macrocephala.The most frequently used drug combination was cassia twig and licorice.The drug categories primarily included phlegm-resolving，interior-warming，and dampness-resolving diuretics; The properties is mainly warm，with a balance of cooling and warming; The flavor is mainly pungent and bitter; The most common meridians is spleen，stomach and lung; In cluster analysis，15 high-frequency traditional Chinese medicines were grouped into seven groups，which had the best effect; two sets of the most commonly used drug pairs were identified through association rule analysis; and six common factors were extracted by factor analysis.Conclusion:Yegui's treatment for swelling disease primarily uses the principle of promoting yang and water flow.He is good at using the Fugui formulation to play the role in warming the middle and invigorating yang，transforming qi and benefiting water.It emphasizing the spleen and lung health，advocating warming and tonifying，and benefiting Tongli.for the focus is on promoting lung，strengthening spleen and and warming kidney，supporting yang and supporting qi，and coordinating the upper and lower bod，ensuring the smooth flow of yang qi throughout the whole body，alleviating water retention，so as to restore the normal functions of qi，blood，fluids，and humors to harmonize yingfen and weifen and naturally eliminating swelling.

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