| 引用本文:孙伟康1，李华南1，2，唐德志3，章晓云1，邵子晨1，袁启鹏1，刘晶1.基于铁死亡理论探讨中医药治疗骨质疏松症的研究进展[J].世界中医药,2024,(07):. |
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| 基于铁死亡理论探讨中医药治疗骨质疏松症的研究进展 |
| Research Progress on Osteoporosis Treated with Traditional Chinese Medicine Based on Ferroptosis Theory |
| 投稿时间：2022-12-01 |
| DOI：10.3969/j.issn.1673-7202.2024.07.025 |
| 中文关键词: 铁死亡 骨质疏松症 中医药 调控机制 铁代谢 活性氧 成骨细胞 破骨细胞 |
| English Keywords:Ferroptosis Osteoporosis Traditional Chinese medicine Regulatory mechanism Iron metabolism ROS Osteoblasts Osteoclasts |
| 基金项目:国家自然科学基金项目（81973883）；第四批全国中医（临床、基础）优秀人才研修项目（国中医药人教发〔2017〕24号）；江西省卫生健康委员会科技计划项目（SKJP_220219224，2021B320）；江西省第二届国医名师邓运明名医工作室（赣人社字〔2021〕201号）；江西省2022年度研究生省级创新专项资金项目（YC2022-s864） |
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| 中文摘要: |
| 铁死亡是一种铁离子参与的新型程序性细胞死亡方式。骨质疏松症作为一种高发代谢性疾病，与铁死亡之间关系密切。中医药对骨质疏松症的防治，具有独特优势。铁死亡理论指导下，如何选择最优的中医药方法，以提高骨质疏松症的治疗效率，是该领域研究亟待解决的问题。铁死亡的主要调控机制与骨质疏松相关。花椒、姜黄、丹参、黄芪、补肾还精方及电针等对骨质疏松症有治疗作用的中医药方法，均可实现不同途径下对铁死亡的干预。推测所纳入的单味中药及复方、电针等均可通过干预铁死亡对骨质疏松症产生调节作用。 |
| English Summary: |
| Ferroptosis is a novel iron ion-involved programmed cell death pathway.Osteoporosis，as a common metabolic disorder，has a close relationship with ferroptosis.Traditional Chinese medicine(TCM) possesses unique advantages in the prevention and treatment of osteoporosis.Under the guidance of ferroptosis theory，how to select the optimal TCM methods to improve the treatment efficiency of osteoporosis is a pressing issue in this field of research.The main regulatory mechanisms of ferroptosis are related to osteoporosis.TCM therapies，such as Zanthoxyli Pericarpium，Curcumae Longae Rhizoma，Salviae Miltiorrhizae Radix et Rhizoma，Astragali Radix，and Bushen Huanjing Formula，as well as electroacupuncture，have therapeutic effects on osteoporosis and can intervene in ferroptosis through different pathways.It is inferred that the included single drugs，compound formulas，electroacupuncture，and other TCM therapies can regulate osteoporosis by intervening in ferroptosis. |
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