To investigate the clinical effect and mechanism of Chaiqin Chengqi Decoction with different compatibility in treating acute pancreatitis(AP).Methods:KM mice were randomly assigned into 6 groups(n=10):blank control，model，and Chaiqin Chengqi Decoction A，B，C，and D.The mouse model of AP was established by intraperitoneal injection of 20% L-arginine.The mice in Chaiqin Chengqi Decoction A，B，C，and D groups were administrated with Chaiqin Chengqi Decoction with different compatibility(crude drug concentration of 1 g/mL) by gavage twice a day for 3 consecutive days.At the time point of 72 h after modeling，the body-to-pancreas ratio and the amylase(AMS) level in the serum were measured，and the pathological changes of the pancreas were observed.The levels of malondialdehyde(MDA) and superoxide dismutase(SOD) in the serum were measured.Results:Chaiqin Chengqi Decoction with different compatibility reduced the body-to-pancreas ratio，alleviated the edema，bleeding，and necrosis of the pancreas，lowered the levels of AMS and MDA，and elevated the level of SOD in the serum of AP mice.Furthermore，group A performed the best in mitigating the pancreatic edema and recovering the serum MDA level of AP mice.Group B showcased the best performance in alleviating the pathological damage in the pancreas and recovering the serum AMS level.Group D demonstrated the best performance in restoring the serum SOD level.Conclusion:Chaiqin Chengqi Decoction with different compatibility alleviated the pancreatic damage in AP mice，with the varied effects due to different compatibility.