| 引用本文:陈丹丹1，孙琛2，宋亮1，卫培峰1.柴芩承气汤干预急性胰腺炎的配伍规律及作用机制[J].世界中医药,2024,(09):. |
|
| 柴芩承气汤干预急性胰腺炎的配伍规律及作用机制 |
| Compatibility and Mechanism of Chaiqin Chengqi Decoction in Treating Acute Pancreatitis |
| 投稿时间：2022-11-18 |
| DOI：10.3969/j.issn.1673-7202.2024.09.006 |
| 中文关键词: 柴芩承气汤 中药 配伍 急性胰腺炎 水肿 坏死 超氧化物歧化酶 丙二醛 |
| English Keywords:Chaiqin Chengqi Decoction Chinese medicine Compatibility Acute pancreatitis Edema Necrosis Superoxide dismutase(SOD) Malondialdehyde(MDA) |
| 基金项目:国家自然科学基金项目（81373988）；陕西省科技厅重点研发计划一般项目-社会发展领域（2019SF-294） |
|
| 摘要点击次数: 217 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨不同配伍的柴芩承气汤治疗急性胰腺炎（AP）的临床效果及作用机制。方法：昆明小鼠采用区组随机化随机分为6组，分别是空白对照组、模型组、柴芩承气汤A组、柴芩承气汤B组、柴芩承气汤C组、柴芩承气汤D组，每组10只。模型组给予20% L-精氨酸腹腔注射复制AP小鼠模型，柴芩承气汤A、B、C、D组在此基础上给予不同配伍的柴芩承气汤（生药浓度1 g/mL）灌胃，2次/d，连续给药3 d。造模后72 h取材，检测小鼠胰腺脏体比、血清淀粉酶（AMS）含量，观察小鼠胰腺病理学改变，并检测血清丙二醛（MDA）和超氧化物歧化酶（SOD）含量。结果：不同配伍的柴芩承气汤均可降低AP小鼠胰腺脏体比，改善胰腺的水肿、出血和坏死程度，降低血清淀粉酶水平，并明显降低血清MDA含量，升高血清SOD含量。柴芩承气汤A组对AP小鼠胰腺水肿和血清MDA含量的改善效果最好，柴芩承气汤B组对AP小鼠胰腺病理损伤和血清淀粉酶含量的改善效果最佳，柴芩承气汤D组对AP小鼠血清SOD含量的改善效果最好。结论：不同配伍的柴芩承气汤均能有效缓解AP小鼠的病变程度，但根据加减药物不同，其干预效果各有侧重。 |
| English Summary: |
| To investigate the clinical effect and mechanism of Chaiqin Chengqi Decoction with different compatibility in treating acute pancreatitis(AP).Methods:KM mice were randomly assigned into 6 groups(n=10):blank control，model，and Chaiqin Chengqi Decoction A，B，C，and D.The mouse model of AP was established by intraperitoneal injection of 20% L-arginine.The mice in Chaiqin Chengqi Decoction A，B，C，and D groups were administrated with Chaiqin Chengqi Decoction with different compatibility(crude drug concentration of 1 g/mL) by gavage twice a day for 3 consecutive days.At the time point of 72 h after modeling，the body-to-pancreas ratio and the amylase(AMS) level in the serum were measured，and the pathological changes of the pancreas were observed.The levels of malondialdehyde(MDA) and superoxide dismutase(SOD) in the serum were measured.Results:Chaiqin Chengqi Decoction with different compatibility reduced the body-to-pancreas ratio，alleviated the edema，bleeding，and necrosis of the pancreas，lowered the levels of AMS and MDA，and elevated the level of SOD in the serum of AP mice.Furthermore，group A performed the best in mitigating the pancreatic edema and recovering the serum MDA level of AP mice.Group B showcased the best performance in alleviating the pathological damage in the pancreas and recovering the serum AMS level.Group D demonstrated the best performance in restoring the serum SOD level.Conclusion:Chaiqin Chengqi Decoction with different compatibility alleviated the pancreatic damage in AP mice，with the varied effects due to different compatibility. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
