世界中医药
文章摘要
引用本文:崔雨婷1,2,张方圆3,许伟明4,李子贇5,胡镜清2,4,6.基于肠道菌群与冠心病的关系探讨“阴火”科学内涵[J].世界中医药,2024,(09):.  
基于肠道菌群与冠心病的关系探讨“阴火”科学内涵
Scientific Connotation of Yin Fire Based on Relationship Between Gut Microbiota and Coronary Heart Disease
投稿时间:2023-01-16  
DOI:10.3969/j.issn.1673-7202.2024.09.010
中文关键词:  肠道菌群  冠心病  阴火  元气失养  炎症  脂代谢  脂多糖  氧化三甲胺
English Keywords:Gut microbiota  Coronary heart disease  Yin fire  Loss of nourishment of original qi  Inflammation  Lipid metabolism  LPS  TMAO
基金项目:国家重点研发计划项目(2019YFC1708501);国家自然科学基金项目(82074316);省部共建中医湿证国家重点实验室项目(SZ2021ZZ01);佛山市科技创新项目(2020001005585)
作者单位
崔雨婷1,2,张方圆3,许伟明4,李子贇5,胡镜清2,4,6 1 南京中医药大学附属医院南京210004 2 省部共建中医湿证国家重点实验室〔广州中医药大学第二附属医院〕广州510120 3 中国科学院杭州高等研究院杭州310058 4 中国中医药科技发展中心北京100027 5 南京中医药大学针灸推拿学院养生康复学院南京210034 6 广东省新黄埔中医药联合创新研究院广州510530 
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中文摘要:
      肠道菌群与冠心病之间有密切的生理病理联系,肠道菌群结构及产物影响冠心病的发生发展。近年来,中医药领域高度关注肠道菌群对疾病的影响,而肠道菌群主要通过炎症损伤血管内皮、造成脂质代谢紊乱、促进血栓形成及氧化应激损伤血管内膜等机制影响冠心病,通过类比发现此机制与中医脾胃失调、元气失养、阴火内生病机过程相通。因此,从“阴火”理论可指导调节肠道菌群,进而治疗冠心病,这将为冠心病的中医药临床防治和科学研究带来新思路。
English Summary:
      There is a close physiological and pathological relationship between the gut microbiota and coronary heart disease(CHD),as the structure and metabolites of the gut microbiota affect the occurrence and development of CHD.In recent years,there has been significant attention in the field of traditional Chinese medicine(TCM) on the influence of the gut microbiota on diseases.The gut microbiota mainly affects CHD through mechanisms such as inflammation-induced endothelial damage,disruption of lipid metabolism,promotion of thrombosis formation,and oxidative stress-induced endothelial damage.By analogy,this mechanism is found to be analogous to the TCM pathogenesis processes of spleen-stomach disharmony,loss of nourishment of original qi,and internal generation of pathogenic factors related to yin-fire imbalance.Therefore,the theory of yin-fire can guide the regulation of the gut microbiota to treat CHD.This approach can provide new perspectives for the clinical prevention and treatment of CHD with TCM,as well as for scientific research in this field.
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