世界中医药
文章摘要
引用本文:聂媛媛1,何嘉琪1,苗华为1,李文关2.心脑宁胶囊对冠心病经皮冠状动脉介入术后心绞痛患者的影响[J].世界中医药,2024,(09):.  
心脑宁胶囊对冠心病经皮冠状动脉介入术后心绞痛患者的影响
Effect of Xinnaoning Capsules on Patients with Angina Pectoris after Percutaneous Coronary Intervention
投稿时间:2022-08-10  
DOI:10.3969/j.issn.1673-7202.2024.09.013
中文关键词:  心脑宁胶囊  经皮冠状动脉介入  术后  动脉粥样硬化  心绞痛  血脂  气滞血瘀证  西雅图心绞痛量表  不良反应
English Keywords:Xinnaoning Capsules  Percutaneous coronary intervention  Postoperative  Atherosclerosis  Angina pectoris  Blood lipids  Syndrome of qi stagnation and blood stasis  Seattle Angina Questionnaire  Adverse reactions
基金项目:国家重点研发计划“中医药现代化研究”重点专项(2018YFC1707402)
作者单位
聂媛媛1,何嘉琪1,苗华为1,李文关2 1 河北中医学院第一附属医院心血管科石家庄050011 2 山东中医药大学附属医院心血管病科济南250011 
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中文摘要:
      目的:探讨心脑宁胶囊对冠心病经皮冠状动脉介入(PCI)术后心绞痛患者的影响。方法:选取2021年5月至2022年3月河北省中医院心血管科收治的冠心病PCI术后合并不同程度心绞痛的患者132例作为研究对象,按照简单随机化(抛硬币)法分为对照组和观察组,每组66例,均给予常规西药治疗,对照组给予安慰剂治疗,观察组给予心脑宁胶囊口服。比较2组患者治疗前后心绞痛发作情况及硝酸甘油减停率、血脂、斑块面积、西雅图心绞痛量表评分以及不良反应。结果:治疗24周后,2组患者心绞痛发作情况、硝酸甘油减停率、三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平均较治疗前明显改善,且观察组更显著(均P<0.05)。2组患者治疗后躯体活动受限程度,心绞痛稳定状态,心绞痛发作情况,治疗满意程度及疾病认知程度均改善(均P<0.05)。结论:心脑宁胶囊联合西药短期治疗冠心病PCI术后心绞痛患者,可减少心绞痛发作次数,缩短心绞痛发作时间,减少抗心绞痛药物用量,有效控制血脂水平,且不良反应少。
English Summary:
      To investigate the effect of Xinnaoning Capsules on angina pectoris in patients with coronary heart disease(CHD) after percutaneous coronary intervention(PCI).Methods:A total of 132 CHD patients with varying degrees of angina pectoris after PCI,admitted to the Department of Cardiovascular Medicine at Hebei Provincial Hospital of Traditional Chinese Medicine between May 2021 and March 2022,were enrolled and divided into a control group and an observation group by simple randomization(coin tossing),with 66 patients in each group.Both groups received conventional western medicine treatment.The control group was given a placebo,while the observation group received Xinnaoning Capsules orally.The incidence of angina attacks,the reduction and discontinuation rate of nitroglycerin,blood lipid levels,plaque area,Seattle Angina Questionnaire scores,and adverse reactions were compared before and after treatment between the two groups.Results:After 24 weeks of treatment,both groups showed significant improvement in the incidence of angina attacks,nitroglycerin reduction and discontinuation rates,triglycerides,total cholesterol,and low-density lipoprotein cholesterol levels compared to the conditions before treatment,with the observation group showing more significant improvement(all P<0.05).After treatment,both groups also showed improvements in physical activity limitations,stability of angina,incidence of angina attacks,treatment satisfaction,and disease awareness(all P<0.05).Conclusion:Xinnaoning Capsules combined with western medicine in the short-term treatment of angina pectoris in CHD patients after PCI can reduce the frequency and duration of angina attacks,decrease the use of anti-angina medications,and effectively control blood lipid levels,with few adverse reactions.
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