| To evaluate the efficacy and safety of oral Chinese patent medicines for the treatment of stable chronic obstructive pulmonary disease(COPD) using network Meta-analysis.Methods:A computer-based search was conducted in the China National Knowledge Infrastructure(CNKI),China Academic Journals Database(CSPD),Chinese Science and Technology Journals Database(CCD),Chinese Biomedical Literature Database(CBM),PubMed,Embase,Web of Science,and Cochrane Library for clinical randomized controlled trials(RCTs) on different Chinese patent medicines for the treatment of stable COPD.The retrieval time was from the establishment of the databases until May 11,2022.Data analysis was performed using R4.1.1,Stata16.0,and Review Manager 5.3 software.Results:A total of 74 RCTs were included,involving 6652 patients and 5 types of Chinese patent medicines.Based on the ranking of cumulative probability values,the network Meta-analysis results were shown as follows.For improving COPD assessment test(CAT) questionnaire scores:Bailing capsules plus conventional treatment(CT) were superior to CT alone.For improving the percentage of forced expiratory volume in one second(FEV1%):Bailing Capsules plus CT were superior to Jinshuibao Capsules plus CT,which were superior to Bufei Huoxue Capsules plus CT,which were superior to Yupingfeng granules plus CT,which were superior to CT alone.For improving the six-minute walk distance(6MWD):Jinshuibao Capsules plus CT were superior to Bufei Huoxue Capsules plus CT,which were superior to Bailing Capsules plus CT,which were superior to CT alone.For reducing the partial pressure of carbon dioxide(PaCO2):Bufei Huoxue Capsules plus CT were superior to Jinshuibao Capsules plus CT,which were superior to Bailing Capsules plus CT,which were superior to CT alone.For reducing the annual number of acute exacerbations:Bailing Capsules plus CT were superior to CT alone.None of the five Chinese patent medicines caused serious adverse reactions.Conclusion:All five Chinese patent medicines can enhance the overall clinical efficacy in the treatment of stable COPD,each with its specific strengths.Among them,Bailing Capsules showed relatively better comprehensive efficacy. |
