| To systematically summarize and analyze the application status of progression-free survival(PFS) outcome indicators in idiopathic pulmonary fibrosis(IPF),and provide a reference for rational clinical use.Methods:A systematic computer search was conducted in PubMed,EMbase,The Cochrane Library,China National Knowledge Infrastructure(CNKI),Chinese Biomedical Literature Database(CBM),China Academic Journals Database(CSPD),and Chinese Science and Technology Journals Database(CCD) for literature related to PFS outcome indicators in IPF.The search period spanned from the establishment of each database until December 31,2022.Relevant literature was screened,data were extracted,and PFS outcome indicators in IPF prevention and treatment studies were organized.The frequency of application and the differences in various single outcome indicators were analyzed.Results:Fifty-one articles were included.The PFS outcome indicator is a commonly used composite endpoint indicator in clinical practice,mainly covering one or more of the following outcome indicators:lung function,lung transplantation,6-minute walk distance(6MWD),mortality,and acute exacerbation of idiopathic pulmonary fibrosis(AE-IPF).Conclusion:Currently,the application standards for PFS outcome indicators in IPF prevention and treatment research are not unified,indicating a need for further improvement,standardization,and unification. |
