Harmonizing method is one of the eight methods of traditional Chinese medicine(TCM) and is widely used.Malignant tumors have a certain rhythm，and the application of circadian rhythm has achieved good results in anti-tumor treatment.However，there is still a lack of effective intervention measures for circadian rhythm disorders.The harmonizing method in regulating circadian rhythm disorders was explored through the three aspects of harmonizing cold-heat，liver-spleen，and Ying-Wei，and the application of the harmonizing method in the treatment of malignant tumors was clarified，so as to provide a reference for the research on tumor chronotherapy in the future.