引用本文:李文娜1,王丽涛2,谈博2,孙一珂2,林红3,马淑然2.基于四季抑郁症患者的神经递质变化探讨“天人相应”生物学内涵[J].世界中医药,2024,(12):. |
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基于四季抑郁症患者的神经递质变化探讨“天人相应”生物学内涵 |
Biological Connotation of Correspondence between Human and Nature rom Neurotransmitters in Patients with Depression in Seasons |
投稿时间:2023-04-12 |
DOI:10.3969/j.issn.1673-7202.2024.12.019 |
中文关键词: 天人相应 神经递质 四季 气象因子 抑郁症 情志 日照时数 气压 气温 |
English Keywords:Correspondence between nature and human Neurotransmitter Four seasons Meteorological factors Depression Emotion Sunshine duration Air pressure Air temperature |
基金项目:国家自然科学基金面上项目(81774162);国家自然科学基金面上项目(81774162) |
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中文摘要: |
目的:观察季节变化对单胺类神经递质的影响,以探讨中医“天人相应”理论的生物学内涵。方法:将65例抑郁组患者以及40例正常组健康人纳入研究。比较四季5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)的水平。搜集四季气象资料,探讨上述四季单胺类神经递质分泌水平与气象因子的相关性。结果:正常组不同神经递质5-HT、DA、NE的四季整体分泌水平分别呈冬季<秋季<春季<夏季、秋季<冬季<夏季<春季、秋季<冬季<春季<夏季的趋势;抑郁组5-HT抑郁组四季分泌水平之间比较差异无统计学意义(P>0.05),抑郁组DA、NE的四季分泌趋势分别为春季<夏季<秋季<冬季、冬季<秋季<春季<夏季。其次,与正常组比较,四季的抑郁组5-HT、NE水平显著降低;春季、夏季的抑郁组DA水平显著降低,秋季、冬季的抑郁组DA水平显著升高。气象因子与单胺类神经递质的相关性主要体现在四季的日照时数、最低气压以及平均最高气温。结论:正常组和抑郁组的血清神经递质存在不同的季节性变化趋势,四季气象因子对人体情绪相关的单胺类神经递质的变化的影响,可能是“天人相应”理论的生物学基础之一。 |
English Summary: |
To explore the biological connotation of the theory of correspondence between human and nature in traditional Chinese medicine based on seasonal changes in monoamine neurotransmitters.Methods:A total of 65 depression patients(depression group) and 40 healthy volunteers(normal group) were included in this study.The levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE),and dopamine(DA) were compared among four seasons.The meteorological data of the four seasons were collected,and the correlations between the secretion levels of the above-mentioned monoamine neurotransmitters and the meteorological factors were evaluated.Results:In the normal group,the overall secretion levels of 5-HT,DA,and NE in four seasons showed the trends of winter0.05),and the secretion levels of DA and NE followed the trends of spring |
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