To explore the biological connotation of the theory of correspondence between human and nature in traditional Chinese medicine based on seasonal changes in monoamine neurotransmitters.Methods:A total of 65 depression patients(depression group) and 40 healthy volunteers(normal group) were included in this study.The levels of 5-hydroxytryptamine(5-HT)，norepinephrine(NE)，and dopamine(DA) were compared among four seasons.The meteorological data of the four seasons were collected，and the correlations between the secretion levels of the above-mentioned monoamine neurotransmitters and the meteorological factors were evaluated.Results:In the normal group，the overall secretion levels of 5-HT，DA，and NE in four seasons showed the trends of winter0.05)，and the secretion levels of DA and NE followed the trends of spring