| 引用本文:邹欣甫1，王得昌1，邹欣妍2，王康锋3，陈泽涛3.基于脑-肠轴理论的便秘型肠易激综合征伴焦虑抑郁中西医认识述要[J].世界中医药,2024,(12):. |
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| 基于脑-肠轴理论的便秘型肠易激综合征伴焦虑抑郁中西医认识述要 |
| Understanding of Constipation-predominant Irritable Bowel Syndrome with Anxiety and Depression Based on Brain-gut Axis Theory from Traditional Chinese and Western Medicine Perspectives |
| 投稿时间：2023-06-27 |
| DOI：10.3969/j.issn.1673-7202.2024.12.020 |
| 中文关键词: 脑-肠轴 肠道菌群 焦虑 抑郁 心理因素 便秘型肠易激综合征 心 肝 脾 |
| English Keywords:Brain-gut axis Gut microbiota Anxiety Depression Psychological factors Constipation-predominant irritable bowel syndrome Heart Liver Spleen |
| 基金项目:国家自然基金青年科学基金项目（81303028）；山东省自然科学基金项目（ZR2020MH354） |
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| 中文摘要: |
| 随着西医学的研究和进展，多数医家认为精神心理状态与便秘型肠易激综合征（IBS-C）二者之间有着明确的联系。脑肠轴在二者的发病机制中皆处于重要的地位，以脑肠互动理论来论治本病已经受到了广泛的关注。西医认为脑-肠肽、肠道菌群失调等因素可导致肠易激综合征腹痛、精神心理状态改变等症状，中医上则多把脑-肠轴理论与中医各证型特点相关联。因此，以脑-肠轴为基点从脑-肠肽、肠道微生物、下丘脑-垂体-肾上腺(HPA)轴、心理因素、中医药治疗方面综述IBS-C伴焦虑抑郁状态的发病机制，为同行在临床的诊疗中提供新的思路。 |
| English Summary: |
| With the research and advancements in Western medicine，most medical experts believe that there is a clear link between the psychological state and constipation-predominant irritable bowel syndrome(IBS-C).The brain-gut axis plays a crucial role in the pathogenesis of both conditions，and the use of brain-gut interaction theory for treating this disease has received widespread attention.According to Western medicine，factors such as brain-gut peptides and imbalances in gut microbiota can lead to symptoms of IBS-C，including abdominal pain and changes in mental and psychological state.Traditional Chinese medicine(TCM) often associates the brain-gut axis theory with different TCM syndrome types.This article reviewed the pathogenesis of IBS-C with anxiety and depression from the perspective of the brain-gut axis，focusing on brain-gut peptides，gut microbiota，hypothalamic-pituitary-adrenal(HPA) axis，psychological factors，and TCM treatment，so as to offer new insights to clinicians for the diagnosis and treatment of this condition. |
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