With the research and advancements in Western medicine，most medical experts believe that there is a clear link between the psychological state and constipation-predominant irritable bowel syndrome(IBS-C).The brain-gut axis plays a crucial role in the pathogenesis of both conditions，and the use of brain-gut interaction theory for treating this disease has received widespread attention.According to Western medicine，factors such as brain-gut peptides and imbalances in gut microbiota can lead to symptoms of IBS-C，including abdominal pain and changes in mental and psychological state.Traditional Chinese medicine(TCM) often associates the brain-gut axis theory with different TCM syndrome types.This article reviewed the pathogenesis of IBS-C with anxiety and depression from the perspective of the brain-gut axis，focusing on brain-gut peptides，gut microbiota，hypothalamic-pituitary-adrenal(HPA) axis，psychological factors，and TCM treatment，so as to offer new insights to clinicians for the diagnosis and treatment of this condition.