The Wnt signaling pathway plays a decisive role in the proliferation and differentiation of stem cells.Increasing studies have proven the definite therapeutic effects of acupuncture on ischemic stroke，in which the Wnt/β-catenin signaling pathway plays a key role.This paper summarizes the existing studies about acupuncture in ameliorating post-infarction injury via this signaling pathway and clarifies the relevant mechanisms and targets，aiming to provide new ideas for the treatment of stroke.