| 引用本文:韩宇1，王雨1，李耀磊2，林志健1，张冰1.龙胆苦苷磁性分子印迹聚合物的制备[J].世界中医药,2024,(13):. |
|
| 龙胆苦苷磁性分子印迹聚合物的制备 |
| Preparation of Magnetic Molecularly Imprinted Polymers of Gentianoside |
| 投稿时间：2024-05-22 |
| DOI：10.3969/j.issn.1673-7202.2024.13.007 |
| 中文关键词: 龙胆苦苷 磁性分子印迹技术 高尿酸血症 秦艽 选择性识别 分离 制备 吸附 |
| English Keywords:Gentianoside Magnetic molecular imprinting technology Hyperuricemia Gentianae Macrophyllae Radix Selective recognition Separation Preparation Adsorption |
| 基金项目:国家自然科学基金联合基金项目（U20A20406）；北京中医药大学双一流-新药研发项目（90010961020091） |
|
| 摘要点击次数: 283 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：应用磁性分子印迹技术，从降尿酸中药秦艽中特异性吸附与分离龙胆苦苷。方法：以龙胆苦苷为模板分子，甲基丙烯酸（MAA）为功能单体，乙二醇二甲基丙烯酸酯（EGDMA）为交联剂，偶氮二异丁腈（AIBN）为引发剂，甲醇为致孔剂，制备龙胆苦苷磁性分子印迹聚合物。通过傅里叶变换红外光谱（FTIP）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）对材料进行表征，通过绘制动力学吸附曲线及静态等温线评价其吸附性能。结果：龙胆苦苷磁性分子印迹聚合物合成成功，震荡60 min基本达到吸附平衡，从秦艽中提取和分离龙胆苦苷，吸附量为6.316 mg/g。结论：降尿酸中药秦艽中的龙胆苦苷可被龙胆苦苷磁性分子印迹聚合物特异性捕获。 |
| English Summary: |
| To apply magnetic molecular imprinting technique for the specific adsorption and isolation of gentianoside from the uric acid-lowering Chinese medicine Gentianae Macrophyllae Radix.Methods:Magnetic molecularly imprinted polymers(MIPs) of gentianoside were prepared using gentianoside as the template molecule，methacrylic acid(MAA) as the functional monomer，ethylene glycol dimethacrylate(EGDMA) as the cross-linker，azobisisobutyronitrile(AIBN) as the initiator，and methanol as the porogenic agent.The materials were characterized using Fourier-transform infrared spectroscopy(FTIR)，scanning electron microscopy(SEM)，and transmission electron microscopy(TEM).The adsorption performance was evaluated by plotting kinetic adsorption curves and static isotherms.Results:The magnetic MIPs of gentianoside was successfully synthesized，and reached the adsorption equilibrium after shaking for 60 min.The adsorption capacity for gentianoside extracted and separated from Gentianae Macrophyllae Radix was 6.316 mg/g.Conclusion:Gentianoside in the uric acid-lowering Chinese medicine Gentianae Macrophyllae Radix can be specifically captured by magnetic MIPs of gentianoside. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
