Guizhi Fuzi Decoction，derived from Treatise on Cold Damage(Shang Han Lun) and Synopsis of the Golden Chamber(Jin Gui Yao Lue)，addresses the syndromes with core pathogenesis of wind-dampness obstruction and healthy qi deficiency with pathogen retention.The main indicated clinical symptoms include generalized pain and restricted movement.The primary therapeutic principles of Guizhi Fuzi Decoction are to dispel wind，dissipate cold，eliminate dampness，and relieve pain.Guizhi Fuzi Decoction，known for its effects of expelling wind，eliminating dampness，warming yang，dissipating cold，and unblocking obstructions to alleviate pain，is a classic prescription in traditional Chinese medicine(TCM) for treating impediment diseases.In modern clinical practice，Guizhi Fuzi Decoction is widely used to treat conditions such as rheumatoid arthritis，gouty arthritis，sciatica，frozen shoulder，and radicular cervical spondylosis，with definite efficacy.The pharmacological mechanisms underlying the therapeutic effects of Guizhi Fuzi Decoction may be closely related to its anti-inflammatory and analgesic properties，immune regulation，and improvement of joint symptoms.