To study the anti-inflammatory and analgesic effects of Rumo ointment in the treatment of acute closed soft tissue injury.Methods:Sixty SD rats(6 spare) were divided into group A(blank control group)，group B(model control group)，group C(Qingpeng ointment group)，group D(high-dose Rumo ointment group)，group E(middle-dose Rumo ointment group)，and group F(low-dose Rumo ointment group).By establishing the SD rat model of acute closed soft tissue injury，the content of tumor necrosis factor-α(TNF-α)，interleukin-1β(IL-1β)，prostaglandin E2(PGE2)，and superoxide dismutase(SOD) was detected in the damaged tissue.The morphological changes of the damaged tissue and the content changes of basic fibroblast growth factor(bFGF) in the tissue were observed under a microscope.Results:After intervention using modeling drugs，the content of TNF-α，IL-1β，and PGE-2 in the injured tissues of rats in the modeling groups gradually decreased，among which the decrease in group C and group D was the most obvious，and the decrease in group B was the slowest.The increase in SOD content was the most obvious in group C and group D，and that in group B was the slowest.On the second day after modeling，there was no significant difference in the average optical density of bFGF protein in each group（P>0.05）.On the 7th and 14th days after modeling，the average optical density of bFGF protein in each group was statistically different（P<0.05）.Conclusion:High-dose Rumo ointment and Qingpeng ointment have comparable anti-inflammatory and analgesic effects.