To systematically review ancient and modern literature on Danggui Shaoyao Powder（DSP) to understand its historical development and clinical application，providing a theoretical basis for its modern clinical use and research.Methods:The term “Danggui Shaoyao Powder” was used to search relevant entries and ancient texts in the Zhonghua Medical Canon database.Additionally，China National Knowledge Infrastructure（CNKI) and PubMed databases were searched using “Danggui Shaoyao Powder” and “Danggui Shaoyao San” as keywords.Articles were selected according to inclusion and exclusion criteria，and the historical evolution and clinical research on DSP were summarized.Results:A total of 111 entries from 50 medical texts were included from ancient literature.DSP was first recorded in the Synopsis of the Golden Chamber（Jin Gui Yao Lue)，and its composition，original sources，dosage，and decoction methods largely followed the descriptions by ZHANG Ji.The original text did not record processing methods，adverse reactions，or contraindications for DSP.However，later physicians and scholars examined and discussed the individual drugs in the formula.The composition ratio of the prescription was identified as 3:16:8:4:4:8，using raw herbs，and it was primarily indicated for abdominal pain.In modern literature，38 studies were included，highlighting the analgesic，anti-inflammatory，hormone-regulating，lipid-lowering，blood circulation-improving，and immune-boosting effects.DSP has been mainly used to treat chronic pelvic inflammatory disease，dysmenorrhea，chloasma，diabetic nephropathy，and other conditions.Conclusion:The composition，original sources，dosage，and methods of decoction and administration of DSP have remained largely consistent with those described in the Synopsis of the Golden Chamber.The formula is mainly applicable to five syndromes and over ten diseases.Clinically，exploring its mechanisms of action has broadened the application range of DSS，providing a reference for the development and use of this classical prescription.