| 引用本文:李林1，李晗2，陈腾飞2，黄鹤1，高云航2，宋玲2，侯红平2，张广平2，杨红1，叶祖光2.诃子、甘草与制草乌配伍对小鼠急性毒性的影响[J].世界中医药,2024,(24):. |
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| 诃子、甘草与制草乌配伍对小鼠急性毒性的影响 |
| Effect of Compatibility of Prepared Aconitum kusnezoffii with Chebulae fructus and Glycyrrhiza uralensis on Acute Toxicity in Mice |
| 投稿时间：2023-01-12 |
| DOI：10.3969/j.issn.1673-7202.2024.24.003 |
| 中文关键词: 草乌 诃子 甘草 配伍 减毒 急性毒性 半数致死数量 扎冲十三味丸 |
| English Keywords:Aconitum kusnezoffii Chebulae fructus Glycyrrhiza uralensis Compatibility Toxicity reduction Acute toxicity Median lethal number Zhachong Shisan Wei Pill |
| 基金项目:国家重点研发计划项目（2018YFC1708200，2018YFC1708204）;内蒙古自治区科技重大专项（2019ZD004） |
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| 中文摘要: |
| 目的：通过观察不同剂量制草乌与诃子、甘草,以及3味药配伍对小鼠急性毒性的影响，从毒性角度探讨诃子和甘草是否对制草乌减毒。方法：采取单次灌胃给药的方式，以加权回归(Bliss)法测定半数致死数量（LD50）并分别对各剂量组进行一般症状观察、体质量和摄食量的测定。结果：制草乌组LD50：798.77 mg/kg，诃子-制草乌组LD50：927.27 mg/kg，甘草-制草乌组LD50：801.28 mg/kg，诃子-甘草-制草乌组LD50：1 080.9 mg/kg。给药后第1天与空白组比较制草乌组小鼠体质量和摄食量显著降低，配伍组体质量和摄食量明显降低。第3天后小鼠体质量和摄食量与空白组比较差异无统计学意义。结论：诃子与甘草对制草乌具有一定减毒作用，其中减毒作用由强至弱依次为诃子-甘草-制草乌组>诃子-制草乌组>甘草-制草乌组。 |
| English Summary: |
| By observing the effect of compatibility of different doses of prepared Aconitum kusnezoffii with Chebulae fructus and Glycyrrhiza uralensis and the combination of the three drugs on acute toxicity in mice，this paper discussed whether Chebulae fructus and Glycyrrhiza uralensis can reduce the toxicity of prepared Aconitum kusnezoffii.Methods:After a single intragastric administration，the median lethal number(LD50) was determined by the Bliss method，and the general symptoms，body weight，and food intake were measured in each dose group.Results:LD50 in the prepared Aconitum kusnezoffii was 798.77 mg/kg，with that in the Chebulae fructus and prepared Aconitum kusnezoffii group being 927.27 mg/kg.LD50 in the Glycyrrhiza uralensis and prepared Aconitum kusnezoffii group was 801.28 mg/kg，and that in the Chebulae fructus，Glycyrrhiza uralensis，and prepared Aconitum kusnezoffii group was 1 080.9 mg/kg.Compared with those in the blank group on the first day after administration，the body weight and food intake of mice in the prepared Aconitum kusnezoffii group were significantly reduced，and the body weight and food intake of mice in the compatibility group were obviously reduced.Conclusion:Chebulae fructus and Glycyrrhiza uralensis can reduce the toxicity of prepared Aconitum kusnezoffii.The toxicity reduction effect in descending order is Chebulae fructus，Glycyrrhiza uralensis，and prepared Aconitum kusnezoffii group>Chebulae fructus and prepared Aconitum kusnezoffii group>Glycyrrhiza uralensis and prepared Aconitum kusnezoffii group. |
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