To explore the mechanism of Jiangfu Fuwei Granules(JFFW) in treating chronic atrophic gastritis(CAG) of spleen-kidney yang deficiency type based on network pharmacology，molecular docking，and in vivo experimental validation.Methods:Network pharmacology and molecular docking techniques were employed to predict the potential targets of JFFW in CAG intervention，followed by validation through animal experiments.Fifty SPF-grade male SD rats were randomly divided into a blank group(n=10) and a modeling group(n=40).The CAG model was induced in the modeling group using N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)，Shengdahuang Granules，and intermittent fasting.After successful modeling，the rats were randomly assigned into three groups：model group，Western medicine group，and Chinese medicine group according to a random number table，with 10 rats in each group.They were administered distilled water，folic acid tablets+rebamipide tablets，or JFFW by gavage for 12 weeks.Hematoxylin-eosin(HE) staining，enzyme-linked immunosorbent assay(ELISA)，real-time PCR，and Western blot were used to assess relevant indicators.Results:Network pharmacology and molecular docking analysis identified tumor necrosis factor(TNF)，Caspase-3，and Caspase-8 as core targets of JFFW in CAG intervention.Experimental results demonstrated that JFFW significantly improved gastric mucosal pathology and increased serum levels of gastrin-17(GAS-17)，pepsinogen Ⅰ(PGⅠ)，and the PGⅠ/PGⅡ ratio in CAG rats(P<0.05).Furthermore，JFFW significantly downregulated mRNA and protein expression of tumor necrosis factor-alpha(TNF-α)，tumor necrosis factor receptor 1(TNFR1)，and TNF receptor-associated death domain protein(TRADD) in gastric tissues while upregulating the expression of Fas-associated death domain protein(FADD)，Caspase-8，and Caspase-3(P<0.05).Conclusion:JFFW alleviates or reverses CAG by regulating the TNF signaling pathway，reducing inflammation，and promoting apoptosis，thereby exerting anti-tumor effects.